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Brun Ulfhake
brun.ulfhake@ki.se
Neurogerontology Group Head
Curriculum Vitae
Publications
Curriculum
Vitae
Name: (given names) Ernst Sigmund Brun Eric
(Surname) Ulfhake
Date of birth: 10 July 1952
Place of birth: Stockholm, Sweden
Citizenship: Swedish
Family: Erika Öjtorp (sambo), Gustaf Ulfhake Öjtorp (son)
Academic degrees:
Läkar examen at Karolinska Institutet, March 1980.
Dr. Med. Sci. at Karolinska Institutet, December 1982.
Docent in Anatomy at Karolinska Institutet, 1988.
Authorization to practice the Medical Profession as a Physician by
The
National Swedish Board of Health and Welfare, 1st of February 1990.
Practice & academic positions
Practice as a physician for approximately 4 years:
Anesthesiology (Södertälje Hospital; 1977-1981) for 2 years;
Internal medicine (Södertälje and Sabbatsbergs Hospitals;
1978-1988), in
total 1 year of practice;
General surgery (Sabbatsbergs Hospital; 1987), for 6 months;
Psychiatry (Beckomberga Hospital; 1989), for 3 months;
General practice (Sabbatsbergs Hospital, outdoor patients; 1989-90)
for
3 months.
Various teaching positions in Anatomy at Karolinska Institutet 1977-
1986.
Associate professor in Anatomy, Department of Neuroscience at Karolinska
Institutet, 1st of January 1986 - present position.
Military service as a medical officer/consultant for submarine personnel
in the
Royal Swedish Navy.
Administrative appointments
Member of Docenturnämnden at Karolinska Institutet 1997-
Member of Stockholms Ethical Committee for animal research (Stockholms
N:a Djurförsöksetiska Nämnd) 1989-
Head of the anatomy teaching department at Karolinska Institutet 1990-1992;
1997-1999.
Member of the Committee for Basic Science Examination of Medical students
at Karolinska Institutet 1996-
Ansvarig föreståndare (supervisor) at the animal research
facility, Nobelsväg 12, Karolinska Institutet, 1989-
Member of the Deans consultant group for issues concerning the use
of animals in medical research at the Karolinska Institutet, 2000- (deputy
chairman).
Member of the committe selecting candidates to the LÄFO (combined
research and medicine) study program at Karolinska Institutet, 2000-
Member of the SALIS board (Styrelsen i sektionen statligt anställda
läkare inom Stockholms läkarförening).
International commissions
Referee appointments:
ad hoc referee Brain Research;
ad hoc referee Neuroscience Letters;
ad hoc referee J. Chemical Neuroanatomy;
ad hoc referee J. Comperative Neurology;
ad hoc referee Experimental Brain Res;
ad hoc referee J. Anatomy and Embryology;
ad hoc referee Neuroscience;
ad hoc referee J. Neurophysiology;
ad hoc referee J. Histochem & Cytochem;
ad hoc referee Europ. J. Neuroscience.
Editorial appointments:
Issue editor NeuroProtocols, Academic Press, USA, 1992.
Deputy receiving editor Europ. J. Neuroscience, 1999-
Review of applications
ad hoc reviewer The New Zeeland Neurological Society
ad hoc reviewer National Academic Foundation (USA)
Other international commissions
Faculty opponent/reviewer at Dr. Bertil Block’s dissertation, Groningen,
The Netherlands, 1998.
International reviewer of Dr M. Wessendorf tenur track application,
University of Minnesota, US (1997).
Publications
PubMed
Original Papers
Reviews
Text book chapters
Appendices
and supplements
Papers indicated by # prefix are relevant to my current research program.
Papers marked with an * prefix are not available on MedLine.
Original
Papers
1979-1982
(Thesis papers; supervisor: J.-O. Kellerth)
1. Ulfhake, B., Kellerth, J.-O., A quantitative light microscopic study
of the dendrites of cat spinal alpha-motoneurons after intracellular staining
with horseradish peroxidase. J.Comp. Neurol. 202:571-583, 1981.
2. Ulfhake, B., Cullheim, S., A quantitative light microscopic study
of the dendrites of cat spinal gamma-motoneurons after intracellular staining
with horseradish peroxidase. J.Comp. Neurol. 202:585-596, 1981.
3. Ulfhake, B., Kellerth, J.-O., Does a-motoneurone size correlate with
motor unit type in cat triceps surae? Brain Res. 251:201-209, 1982.
4. Ulfhake, B., Kellerth, J.-O., A quantitative morphological study
of HRP-labelled cat alpha-motoneuronse supplying different hindlimb muscles.
Brain Res. 264: 1-19, 1983.
5. Ulfhake, B., Kellerth, J.-O., Electrophysiological and morphological
measurements in cat gastrocnemius and soleus alpha-motoneurones. Brain
Res. 307: 167-179, 1984.
1979-1984
(Non-Thesis papers)
6. Cullheim, S., Ulfhake, B., Observations on the morphology of intracellularly
stained a-motoneurons in relation to their axon conduction velocity. Neurosci.
Lett. 13:47-50, 1979.
7. Cullheim, S., Ulfhake, B., Relation between cell body size, axon
diameter and axon conduction velocity of triceps surae motoneurons during
the postnatal development in the cat. J.Comp. Neurol. 188:679-687, 1979.
8. Cullheim, S., Ulfhake, B., Evidence for a postnatal elimination of
terminal arborizations and synaptic boutons of recurrent motor axon collaterals
in the cat. Dev. Brain Res. 5:234-237, 1982.
9. Ulfhake, B., A morphometric study of soma, first-order dendrites
and proximal axon of cat alpha-motoneurones intracellularly labelled with
HRP. Exp.Brain Res. 56: 327-334, 1984.
1985
10. Cullheim, S., Ulfhake, B., Postnatal changes in the termination
pattern of recurrent axon collaterals of triceps surae alpha-motoneurons
in the cat. Dev. Brain Res. 17:63-73, 1985.
11. Remahl, S., Cullheim, S., Ulfhake, B., Dimensions and branching
patterns of triceps surae a-motor axons and their recurrent axon collaterals
in the spinal cord during the postnatal development in the cat. Dev.Brain
Res. 23:193-200, 1985.
1986
12. Gollvik,L., Kellerth, J.-O., Ulfhake, B., The effects of tenotomy
and compensatory hypertrophy on the postnatal development of soleus motor
units in the cat. Acta Physiol. Scand. 126: 565-573, 1986.
13. Ulfhake, B., Örnung, G., Cullheim, S., Electron microscopic
observations on recurrent axon collateral boutons of a triceps surae g-motoneuron
in the cat. Neurosci.Lett. 63:27-32, 1986.
14. Gollvik, L., Kellerth, J.-O., Ulfhake, B., The effects of tenotomy
and overload on the postnatal development of medial gastrocnemius motor
units in the cat. Acta Physiol. Scand. 128:485-494, 1986.
15. Lagerbäck, P.-Å., Cullheim,S., Ulfhake, B., Electron
microscopic observations on the synaptology of cat sciatic g-motoneurons
after intracellular staining with horseradish peroxidase. Neurosci. Lett.
70:23-27, 1986.
1987
16. Lagerbäck, P-Å., Ulfhake, B., Ultrastructural observations
on beaded a-motoneuron dendrites. Acta Physiol. Scand. 129: 61-66, 1987.
17 Ulfhake, B., Arvidsson,U., Cullheim,S., Hökfelt,T. Visser,T.J.,
Thyrotropin-releasing hormone (TRH)-immunoreactive boutons and nerve cell
bodies in the dorsal horn of the cat L7spinal cord. Neurosci. Lett. 73:3-8,
1987.
18. Ulfhake, B., Arvidsson,U., Cullheim,S., Hökfelt,T., Brodin,E.,
Verhofstad,A., Visser, T., An ultrastructural study of 5-hydroxy-tryptamine-,
Thyrotropin-releasing hormone- and substance P- immunoreactive axonal boutons
in the motor nucleus of spinal cord segments L7-S1 in the adult cat. Neuroscience
23: 917-929, 1987.
19. Ulfhake, B., Cullheim, S., Hökfelt, T., Visser, T.J., The combined
use of immunohistochemistry and intracellular staining with horseradish
peroxidase for light and electron microscopic studies of transmitter-identified
inputs to functionally characterized neurons. Brain Res. 419: 387-391,
1987.
1988
20. Gollvik, L., Kellerth, J.-O., Ulfhake, B., The effects of tenotomy
and overload on the postnatal development of muscle fibre histochemistry
in the cat triceps surae. Acta Physiol. Scand. 132:353-362, 1988.
21. Ulfhake, B., Cullheim, S., Fransson, P., Postnatal development of
cat hindlimb motoneurons. I. Changes in length, branching structure, and
spatial distribution of dendrites of cat triceps surae motoneurons. J.Comp.
Neurol., 278: 69-87, 1988.
22. Ulfhake, B., Cullheim, S., Postnatal development of cat hindlimb
motoneurons. II. In vivo morphology of dendritic growth cones and the maturation
of dendrite morphology. J.Comp.Neurol.278: 88-102, 1988.
23. Ulfhake, B., Cullheim, S., Postnatal development of cat hindlimb
motoneurons. III. Changes in size of motoneurons supplying the triceps
surae muscle. J.Comp. Neurol. 278:103-120, 1988.
1989
24 Carlstedt, T., Cullheim, S., Risling, M., Ulfhake, B., Nerve fibre
regeneration across the PNS-CNS interface at the root-spinal cord junction.
Brain Res. Bull. 12: 93-102, 1989.
25. Cullheim, S., Carlstedt,T., Risling, M., Ulfhake, B., Motoneurons
reinnervate skeletal muscle after central root implantation into the spinal
cord. Neuroscience, 29:725-733, 1989.
26. Arvidsson,U., Cullheim, S., Ulfhake, B., Hökfelt,T., Terenius,L.,
Altered levels of calcitonin gene-related peptide (CGRP)-like immunoreactivity
of cat lumbar motoneurons after chronic spinal cord transection. Brain
Res., 489:387-390, 1989.
*27. Mossberg, K., Ulfhake, B., Arvidsson, U., Automated bouton counting
in three dimensions. Proc. SCIA 2:782-785, 1989.
1990
28. Gollvik, L., Örnung, G., Kellerth, J.-O., Ulfhake, B., Anatomy
of soleus a-motoneurone dendrites in normal cats and in cats subjected
to chronic postnatal tenotomy or overload of the soleus muscle. Exp. Brain
Res., 80:34-43, 1990.
29. Mossberg, K., Arvidsson, U., Ulfhake, B., Computerized quantification
of immunofluorescence labeled axon terminals and analysis of co-localization
of signal substances in axon terminals with a confocal scanning laser microscope.
J. Histochem. Cytochem., 38:179-190, 1990.
30. Avidsson, U., Johnson, H., Piehl, F., Cullheim, S., Hökfelt,
T., Risling, M., Terenius, L., Ulfhake, B., Peripheral nerve section induces
increased levels of calcitonin gene-related peptide (CGRP)-like immunoreactivity
in axotomized motoneurons. Exp. Brain Res. 79:212-216, 1990.
31. Carlstedt, T., Risling, M., Lindå, H., Cullheim, S., Ulfhake,
B., Sjögren, A.M., Regeneration after spinal nerve root injury. Restorative
Neurology and Neuroscience, 1:289-295, 1990.
32. Arvidsson, U. Cullheim, S., Ulfhake, B., Bennett, G.W., Fone, K.C..F.,
Cuello, A.C., Verhofstad, A.A.J., Visser, T.J., Hökfelt, T., 5-hydroxitryptamine,
substance P and Thyrotropin-releasing hormone in the adult cat spinal cord
segment L7: Immunohistochemical and chemical studies. Synapse 6:237-270,
1990.
*33. Mossberg, K., Ulfhake, B., Automated analysis of axon terminals
from 3D-data recorded with a confocal scanning laser microscope. Trans.
The Royal Microscopical Soc., 1:413-416, 1990.
34. Arvidsson, U., Schalling, M., Cullheim, S., Ulfhake, B., Terenius,
L., Verhofstad, A., Hökfelt, T., Evidence for coexistence between
calcitonin gene-related peptide and serotonin in the bulbospinal pathway
in the monkey. Brain Res., 532:47-57, 1990.
35. Örnung, G., Ulfhake, B., Changes in size and shape during histochemical
processing for light and electron microscopy of neurons intracellularly
labelled with horseradish peroxidase. Acta Physiol. Scand., 140:501-506,
1990.
36. Lindå, H., Cullheim, S., Risling, S., Arvidsson,U., Mossberg,K.,
Ulfhake, B., Terenius, L., Hökfelt, T., Enkephalin-like immunoreactivity
levels increase in the motor nucleus after an intramedullary axotomy of
motoneurons in the adult cat spinal cord. Brain Res., 534:352-356, 1990.
1991
37. Arvidsson, U., Ulfhake, B., Cullheim, S., Bergstrand, A., Theodorsson,
E., Hökfelt, T., Distribution 125I-galanin binding sites, immunoreactive
galanin, and its coexistence with 5-hydroxytryptamine in the cat spinal
cord: Biochemical, histochemical, and experimental studies at the light
and electron microscopic level. J.Comp. Neurol., 308:115-138, 1991.
#38. Phiel, F., Arvidsson, U., Johnson, H., Cullheim, S., Villar, M.,
Dagerlind, Å., Terenius, L., Hökfelt, T., Ulfhake, B., Calcitonin
gene-related peptide (CGRP)-like immunoreacitivity and CGRP mRNA in rat
spinal cord motoneurons after different types of lesions. European J.Neurosci.
3:737-757, 1991.
39. Arvidsson, U., Ulfhake, B., Cullheim, S., Terenius, L., Hökfelt,
T., Calcitonin gene-related peptide in monkey spinal cord and medulla oblongata.
Brain Res., 558:330-334, 1991.
40. Ramirez, V., Ulfhake, B., Postnatal development of cat hindlimb
motoneurons supplying the intrinsic muscles of the foot sole. Dev. Brain
Res., 62:189-202, 1991.
41. Ulfhake, B., Carlsson, K., Mossberg, K., Arvidsson, U., Helm, P.J.,
Imaging of fluorescent neurons labelled with fluoro-gold and fluorescent
axon terminals labelled with AMCA (7-amino-4-methylcoumarine-3-acetic acid)
conjugated antiserum using a UV-laser confocal scanning microscope. J.
Neurosci. Meth., 40:39-48, 1991.
1992
#42. Ramirez, V., Ulfhake, B., Anatomy of dendrites in motoneurons supplying
the intrinsic muscles of the foot sole in the aged cat: Evidence for dendritic
growth and neosynaptogenesis. J. Comp. Neurol.,316:1-16, 1992.
43. Arvidsson, U., Ulfhake, B., Cullheim, S., Ramirez, V., Shupliakov,
O., Celio, M.R., Hökfelt, T., Distribution of calbindin D28k-like
immunoreactivity (LI) in the monkey ventral horn: Do Renshaw cells contain
calbindin D28k-LI? J. Neuroscience, 12:718-728, 1992.
44. Arvidsson, U., Cullheim, S., Ulfhake, B., Ramirez, V., Dagerlind,
Å., Luppi, P.H., Kitahama, K., Jouvet, M., Terenius, L., Aman, K.,
Hökfelt., T., Distribution of enkephalin and its relation to serotonin
in cat and monkey spinal cord and brain stem. Synapse, 11:85-104, 1992.
#45. Burke, R.E., Marks, W.B., Ulfhake, B., A parsimonious description
of motoneuron dendritic morphology using computer simulation. J. Neuroscience,
12:2403-2416, 1992.
46. Arvidsson, U., Ulfhake, B., Cullheim, S., Shupliakov, O., Brodin,
E., Franck, J., Bennett, G.W., Fone, K.C.F., Visser, T.J., Hökfelt,
T., Thyrotropin-releasing hormone (TRH)-like immunoreactivity in the grey
monkey (Macaca fascicularis) spinal cord and medulla oblongata with special
emphasis on the bulbospinal tract. J. Comp. Neurol., 322:293-310, 1992.
47 Arvidsson, U., Risling, M., Cullheim, S., Dagerlind, Å., Lindå,
H., Shupliakov, O., Ulfhake, B., Hökfelt, T., On the distribution
of GAP43 and its relation to Serotonin in the adult Monkey and cat spinal
cord and lower brainstem. Eur. J. Neurosci.,4:777-784, 1992.
48. Piehl, F., Arvidsson, U., Johnson, H., Dagerlind, Å., Hökfelt,
T., Terenius, L., Ulfhake, B. Reappearance of calcitonin gene-related peptide-like
immunoreactivity in the dorsal horn in long-term dorsal root transected
rat. Brain Res., 585:400-404, 1992.
#49. Johnson, H., Hökfelt, T., Ulfhake, B., Galanin- and CGRP-like
immunoreactivity coexist in rat spinal motoneurons. NeuroReport, 3:303-306,
1992
50. Lindå, H., Piehl, F., Dagerlind, Å., Verge, V.M.K.,
Arvidsson, U., Cullheim, S., Risling, M., Ulfhake, B., Hökfelt, T.,
Expression of GAP-43 mRNA in the adult mammalian spinal cord under normal
conditions and after different types of lesions, with special reference
to motoneurons. Exp. Brain Res., 91:284-295, 1992.
1993
#*51. Johnson, H., Mossberg, K., Ulfhake, B. The size, number and fluorescence
intensity of 5HT-immunoreactive axon terminals in the aged rat lumbar spinal
cord motor nucleus as revealed by confocal fluorescence microscopy and
computerized 3D image analysis. NeuroProtocols 2:101-112, 1993.
#52. Hans Johnson, Brun Ulfhake, Åke Dagerlind, J.F. Bennet, F.P.
Fone, and Tomas Hökfelt, The Serotoninergic Bulbospinal System and
Brainstem-Spinal cord content of Serotonin-, TRH- and substance P-Like
Immunoreactivity in the Aged Rat with Special Reference to the Spinal Cord
Motor Nucleus, Synapse 15:63-89, 1993.
53. Ramírez, V., Ulfhake, B., GABA-like immunoreactive innervation
of the ventrolateral motor nucleus in the cat S1 spinal cord segment: An
electron microscopic study. Exp. Brain Res.,97:1-12, 1993.
54. Shupliakov, O., Örnung, G., Brodin, L., Ulfhake, B., Ottersen,
O.P., Storm-Mathisen, J., Cullheim, S., Immunohistochemical localization
of amino acids neurotransmitter candidates in the ventral horn of the cat
spinal cord. Exp. Brain Res 96:404-418, 1993.
#55. Phiel, F., Arvidsson, U., Johnson, H., Cullheim, S., Dagerlind,
Å., Ulfhake, B., Cao, Y., Elde, R., Pettersson, R.F., Terenius, L.,
Hökfelt, T., GAP-43, aFGF, CCK, a- and b-CGRP in rat spinal motoneurons
subjected to axotomy and/or dorsal root severence. Europ. J.Neurosci, 5:1321-1333,
1993
1994
*56. Ulfhake, B., Carlsson, K., Mossberg, K, Wallén, P., Preparation,
staining and examination of nervous tissue in the confocal scanning laser
microscope. Neuroscience Protocols (Elsevier), 3:65-92, 1994.
57. Arvidsson, U., Cullheim, S., Ulfhake, B., Luppi, P.-H., Kitahama,
K., Jouvet, M., Hökfelt, T., Quantitative and qualitative aspects
on the distribution of 5-HT and its coexistence with substance P and TRH
in cat ventral medullary neurons. J.Chemical Neuronatomy, 7:3-12, 1994.
58. Ramírez-León, V., Hökfelt, T., Cuello, A.C.,
Visser, T., Ulfhake, B. Enkephalin-, thyrotropin-releasing hormone- and
substance P- immunoreactive axonal innervation of the ventrolateral dendritic
bundle in the cat sacral spinal cord: an ultrastructural study. J.Chemical
Neuroanatomy,7:203-214, 1994.
59. Ramírez-León, V., Ulfhake, B., Arvidsson, U., Verhofstad,
A.A.J., Visser, T.J., and Hökfelt, T., Serotoninergic, peptidergic
and GABAergic innervation of the ventrolateral and dorsolateral motor nuclei
in the cat S1/S2 segments: An immunofluorescence study. J.Chemical Neuroanatomy,
7:87-103 1994.
1995
#60. Johnson, H., Mossberg, K., Arvidsson, U., Hökfelt, T.,and
Ulfhake, B., Increases in alpha-CGRP and GAP-43 in aged motoneurons. An
study of peptides, growth factors, and ChAT mRNA in the lumbar spinal cord
of senescent rats with symptoms of hindlimb incapacities. J.Comp. Neurol.,359:1-21,
1995
61. Brismar, H., Trepte, O. and Ulfhake, B. Spectra and fluorescent
lifetimes of LRSC, TRITC, Texas red and Cyanine-3.18 fluorophores: Influences
of some environmental factors recorded with a confocal laser scanning microscope.
J. Histochem. Cytochem., 43:699-708, 1995.
*62. Brismar, H. and Ulfhake, B. Confocal microscopy of multiple stained
biological specimens using fluorescence lifetimes. SPIE 2412:50-55,
1995.
#63. Meister, B., Johnson, H. and Ulfhake, B. Increased expression of
serotonin transporter messenger RNA in raphe reurons of the aged rat. Mol.
Brain Res., 33:87-96, 1995
64. Carlsson, K. and Ulfhake, B. Improved fluorophore separation with
IMS confocal microscopy. NeuroReport, 6:1169-1173, 1995.
65. Örnung, G., Ragnarson, B., Grant, G., Ottersen, O. P., Storm-mathisen,
J. and Ulfhake, B. Ia boutons to CCN neurons and motoneurons are enriched
in glutamate-like Immunoreactivity. NeuroReport, 6:1975-1980, 1995.
*66. Carlsson, K. and Ulfhake, B., Two-color confocal fluorescence microscopy
with improved channel separation: applications to neuroscience. Zoological
Studies 34:56-58, 1995.
1996
67. Örnung, G., Shupliakov, O., Lindå, H., Ottersen, O.-p.,
Storm-mathisen, J., Ulfhake, B. and Cullheim, S. A qualitative and quantitative
analysis of glycine- and GABA-immunoreactive nerve terminals on motoneuron
cell bodies in the cat spinal cord: a postembedding electron microscopic
study. J.Comp. Neurol., 363:413-426, 1996
#68. Johnson, H., Hökfelt, T. and Ulfhake, B. Decreased expression
of TrkB and TrkC mRNAs in spinal cord motoneurons of aged rats. Europ.
J.Neuroscience, 8: 494-499, 1996.
#69. Bergman, E., Johnson, H., Zhang, X., Hökfelt, T. and Ulfhake,
B., Neuropeptides and neurotrophin receptors mRNA in primary sensory
neurons of aged rats. J.Comp. Neurol., 374:1-18, 1996
1997
#70. Brismar, H. and Ulfhake, B., Fluorescence lifetimemeasurements
in confocal microcopy of tissue labelled with multiple fluorophores: Neuropeptides
in axon varicosities of rat spinal cord and DRGs. Nature: BioTechnology,
15: 373-377 1997.
#71. Fundin, B.T., Bergman, E., and Ulfhake, B., Alterations in mystacial
pad innervation in the aged rat. Exp. Brain Res. 117:324-340, 1997.
1998
72. Örnung, G., Ottersen, O.P.; Storm-Mathisen, J., Cullheim, S.,
Ulfhake, B., Distribution of Glutamate-, Glycine- and GABA-immunoreactive
nerve terminals on dendrites in the cat spinal motor nucleus. Exp. Brain
Res., 118:517-532, 1998.
73. Ragnarson, B., Örnung, G., Ottersen, O.P., Grant, G., Ulfhake,
B., Ultrastructural detection of neuronally transported choleragenoid by
postembedding immunocytochemistry in freeze-substituted Lowicryl HM20 embedded
tissue. J. Neuroscience Methods, 80:129-136, 1998.
#74. Bergman, E., Ulfhake, B., Loss of primary sensory neurons in the
very old rat: Neuron number estimates using the disector method and confocal
microscopy. J. Comp. Neurol., 396:211-222, 1998.
#75. Kullberg, S., Ramírez-León, V., Johnson, H., Ulfhake,
B., Decreased axosomatic input to motoneurons and astrogliosis in the spinal
cord of aged rats. J. Gerontology: Biological Sciences, 53A:B369-B379,
1998.
1999
#76. Bergman, E., Fundin, B.T. and Ulfhake, B., Effects of aging and
axotomy on the expression of neurotrophin receptors in primary sensory
neurons. J. Comp. Neurol., 410:368-386, 1999.
#77. Johnson, H., Hökfe1t, T. and Ulfhake, B., Expression of p75NTR,
trkB and trkC in nonmanipulated and axotomized motoneurons of aged rats.
Mol. Brain Res, 69:21-34, 1999.
#78. Bergman, E., Kullberg, S, Ming, Y. and Ulfhake, B., Upregulation
of GFR-a1 and c-ret in primary sensory neurons and spinal motoneurons of
aged rats. J. Neuroscience Research,57:153-165, 1999.
#79. Vania Ramírez-León, Susanna Kullberg, Ole Petter
Hjelle, Ole Petter Ottersen, and Brun Ulfhake, Increased glutathione levels
in neurochemically identified fibre systems in the aged rat lumbar motor
nucleus. Europ. J. Neuroscience, 11:2935-2948, 1999.
#80. Ming, Y., Bergman, E., Edström, E. and Ulfhake, B., Evidence
for increased GDNF signaling in aged sensory and motor neurons. NeuroReport,
10:1529-1535, 1999.
#81 Bergman, E., Carlsson, K., Liljeborg, A., Manders, E., Hökfelt,
T. and B. Ulfhake, Neuropeptides, nitric oxide synthase (NOS), and GAP-43
in B4-binding and RT97 immunoreactive primary sensory neurons: Normal distribution
pattern and changes after peripheral nerve transection and aging. Brain
Res.,832:63-83, 1999.
#82. Ming, Y., Bergman, E., Edström, E. and Ulfhake, B., Reciprocal
changes in the expression of neurotrophins in target tissues and peripheral
nerves during aging Neuroscience Letters, 273:187-190, 1999.
2000
#83. Bergman, E., Ulfhake, B., and Fundin, B.T., Regulations of NGF-family
Ligands and Receptors in Adulthood and Senescence: Correlation to Degenerative
and Regenerative Changes in the Cutaneous Innervation. Europ. J. Neuroscience,
12:2694-2706, 2000.
2001
#84. Kullberg, S., Aldskogius, H. and Ulfhake, B., Pattern of microglial
activation and clusterin upregulation in macroglia in the aging rat CNS.
Brain Research, in press, 2001
Reviews
1. Hökfelt,T., Schalling, M., Arborelius, L., Freedman, J., Arvidsson,
U., Ulfhake, B., Cullheim, S., Brodin, E., Herrera-Marschitz, M., Reid,
M., Ungerstedt, U., Post, C., Kåhrström, J., Owman, C., Tachykinins
in the central nervous system. Regulatory Peptides, 20:6-8, 1988.
2. Carlstedt,T., Cullheim,S., Risling, M., Ulfhake, B., Mammalian root-spinal
cord regeneration. Progr.Brain Res. 78: 225-229, 1988.
3. Hökfelt,T., Tsuruo,Y., Ulfhake, B., Cullheim, S., Arvidsson,
U., Foster, G., Schultzberg, M., Schalling, M., Arborelius, L., Freedman,
J., Post, C., Visser,T., Distribution of TRH-like immunoreactivity with
special reference to coexistence with other neuroactive compounds. N.Y.
Acad. Sci. 553:76-105, 1989.
4. Cullheim, S., Ulfhake, B., Postnatal synaptic reorganization of cat
motoneurons. In: Wenner-Gren International Symposia Series: Neurobiology
of early infant behaviour. Eds: Lagerkrans, v. Euler and Forssberg., 55:51-58,
1990.
5. Cullheim, S., Arvidsson, U., Ulfhake, B., Hökfelt, T., Christenson,
J., Brodin, L., Wallen, P., Grillner, S., Serotonin and coexisting peptides
in cat and lamprey spinal cord. In R. Paoletti et al., (eds), Serotonin:
From cell biology to pharmacology and therapeutics. pp: 149-154, 1990.
6. Hökfelt., T., Arvidsson, U., Ceccatelli, S., Cortes, R., Cullheim,
S., Dagerlind, Å., Johnson, H., Piehl, F., Schalling, M., Terenius,
L., Ulfhake, B., Verge, V., Villar, M., Wiesenfeld-Hallin, S.,Xu, X., Zang,
Distribution of CGRP in the CNS and the sensory nervous system. In: Calcitonin
gene-related peptide, Taché, Y., Holzer, P., Rosenfeld, M.G. (eds).
Proc. N.Y. Acad. Sci. 657:119-134, 1992.
7. Ulfhake, B., Carlsson, K., Mossberg, K., Arvidsson, U., Confocal
fluorescence microscopy in 3D quantitative analysis of axon terminal distribution,
neuronal connectivity and co-localization of messenger-molecules in nervous
tissue. In: Methods in Neuroscience; Conns, M.P. (Ed.); vol 10: 94-128,
1992.
8. Ulfhake, B., Carlsson, K., Mossberg, K., Confocal Microscopy in Neurobiology
(editorial overview). NeuroProtocols, 2:75-77 , 1993.
9. Arvidsson, U., Piehl, F, Johnson, H., Ulfhake, B., Cullheim, S.,
Hökfelt, T. The peptidergic motoneuron. NeuroReport, 4:849-856, 1993.
10. Carlsson, K., Ulfhake, B., Two-color confocal fluorescence microscopy
with improved channel separation; Applications in chemical neuroanatomy.
In: Focus on Multidimensional Microscopy; Eds. J.L. Cheng et al., Word
Scientific Publ. Co. Ltd., New Jersey-Singapor-London, Vol. 1, pp 26-33,
1999.
11. Hökfelt, T., Arvidsson, U., Cullheim, S. , Millhorn, D., Nicholas,
A.P., Pieribone, V., Seroogy, K., Ulfhake, B., Multiple messengers
in descending serotonin neurons: Localization and functional implications.
J. Chemical Neuroanatomy, 18:75-86, 2000.
12. Ulfhake, B., Bergman, B., Edtsröm E., Fundin, B., Johnson,
H., Kullberg, S., Ming, Y., Regulations of neurotrophin signaling in aging
sensory and motoneurons: Dissipation of target support? Molecular NeuroBiology,
in press, 2000.
Text
book chapters
1. Cullheim, S., Ulfhake, B., The development of synaptic connections
in the nervous system. In: Perinatal and Pediatric Physiology-a clinical
perspective; Gluckman, P.D., Heyman, M.A. (eds.),pp 210-215, 1993.
Appendices
and supplements
1. Ulfhake, B., On the dendritic trees of motoneurones in the lumbosacral
spinal cord of the cat. Thesis, Karolinska Institutet, 1982.
2. Örnung, G., Tabar, G., Cullheim, S. and Ulfhake, B., Is single-section
analysis of axo-somatic boutons characteristics useful in studies of motoneuron
synaptology. Appendix, pp 28-35, ISBN 91-628-2402-3, 1997.
3. Bergman, E., Edström, E., Johnson, H., Kullberg, S., Ming, Yu.
and Ulfhake, B., Behavioral, survival and mortality data 1994-1999, Appendix,
pp. 1-13; ISBN 91-628-3900-4, 1999.
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