The Nobel Institute for Neurophysiology
Recent articles
Grillner S, Robertson B. (2015) The basal ganglia downstream control of brainstem motor centres - and evolutionarily conserved stratergy. Curr Opin Neurobiol 33:47-52.
Ocaña FM, Suryanarayana SM, Saitoh K, Kardamakis AA, Capantini L, Robertson B, Grillner S. (2015) The lamprey pallium provides a blueprint of the mammalian motor projections from cortex. Curr Biol 25:413-423.
Grillner S, El Manira A (2015) The intrinsic operation of the networks that make us locomote. Curr Opin Neurobiol 31:244-249.
Pèrez-Fernández J, Stephenson-Jones M, Suryanarayana SM, Robertson B, Grillner S. (2014) Evolutionary conserved organization of the dopaminergic system in lamprey: SNc/VTA afferent and efferent connectivity and D2 receptor expression. J Comp Neurol 522:3775-3794.
Robertson B, Kardamakis A, Capantini L, Pérez-Fernández J, Suryanarayana S, Wallén P, Stephenson-Jones M, Grillner S. (2014) The lamprey blueprint of the mammalian nervous system. Prog Brain Res 212:337-349.
El Manira A, Grillner S. (2014) Motion with direction and balance. Neuron 83:515-517.
Grillner S. (2014) Megascience efforts and the brain. Neuron. 82:1209-1211.
Jalalvand E, Robertson B, Wallén P, Hill RH, Grillner S. (2014) Laterally projecting cerebrospinal fluid-contacting cells in the lamprey spinal cord are of two distinct types. J Comp Neurol 522:1753-1768.
Wang D, Grillner S, Wallén P. (2014) Endogenous release of 5HT modulates the plateau phase of NMDA induced membrane potential oscillations in lamprey spinal neurons. J Neurophysiol 112:30-38.
Cinelli E, Mutolo D, Robertson B, Grillner S, Contini M, Pantaleo T, Bongianni F. (2014) GABAergic and glucinergic inputs modulate rhythmogenic mechanisms in the lamprey respiratory network. J Physiol 592:1823-1838.
Koslov AK, Kardamakis AA, Hellgren Kotaleski J, Grillner S. (2014) Gating of steering signals through phasic modulation of reticulospinal neurons during locomotion. Proc Natl Acad Sci USA Feb 14 (Epub ahead of print).
Stephenson-Jones M, Kardamakis AA, Robertson B, Grillner S. (2013) Independent circuits in the basal ganglia for the evaluation and selection of actions. Proc Natl Acad Sci USA 110:E3670-9.
Ericsson J, Stephenson-Jones M, Perez-Fernandez J, Robertson B, Silberberg G, Grillner S. (2013) Dopamine differentially modulates the excitability of striatal neurons of the direct and indirect pathways in lamprey. J Neurosci 33:8045-54.
Grillner S, Robertson B, Stephenson-Jones M. (2013) The evolutionary origin of the vertebrate basala ganglia and its role in action-selection. J Physiol Feb 25.
Ericsson J, Stephenson-Jones M, Kardamakis A, Robertson B, Silberberg G, Grillner S. (2013) Evolutionary conserved differences in pallial and thalamic short-term synaptic plasticity in striatum. J Physiol 591:859-74.
Wang D, Grillner S, Wallén P. (2013) Calcium dynamic during MNDA-induced membrane potential oscillations in the lamprey spinal neurons - contributions of L-type calcium channels (CaV1.3). J Physiol 591:2409-21.
Cinelli E, Robertson B, Mutolo D, Grillner S, Pantaleo T, Bongianni F. (2013) Neuronal Mechanisms of Respiratory Pattern Generation are Evolutionary Conserved. J Neurosci 33:9104-9112.
Hsu LJ, Zelenin PV, Grillner S, Orlovsky GN, Deliagina TG. (2013) Intraspinal stretch receptor neurons mediate different motor responses along the body in lamprey. J Comp Neurol 521:3847-3862.
Thörn-Perez C, Hill RH, Grillner S. (2013) Modulation of calcium currents and membrane properties by substance P in the lamprey spinal cord. J Neurophysiol 110:286-96.
Robertson B, Huerta-Ocampo I, Ericsson J, Stephenson-Jones M, Perez-Fernandez, Bolam JP, Diaz-Heijtz R, Grillner S. (2012) The dopamine D2 receptor gene in the lamprey, its expression in the striatum and cellular effects of D2 receptor activation. PloS One. 7(4):e35642.
Stephenson-Jones M, Ericsson J, Robertson B, Grillner S. (2012) Evolution of the basal ganglia: dual output pathways conserved throughout vertebrate phylogeny. J Comp Neurol 520:2957-73.
Stephenson-Jones M, Flores O, Robertson B, Grillner S. (2012) Evolutionary conservation of the habenular nuclei and their circuitry controlling the dopamine and 5-hydroxytryptophan (5-HT) systems. Proc Natl Acad Sci USA109:E164-73.
Grillner S (2011) Human locomotor circuits conform. Science 334:912-913.
Stephenson-Jones M, Samuelsson E, Ericsson J, Robertson B, Grillner S. (2011) Evolutionary Conservation of the Basal Ganglia as a Common Vertebrate Mechanism for Action Selection. Curr Biol, 21:1081-1091.
Ericsson J, Silberberg G, Robertson B, Wikström MA, Grillner S. (2011) Striatal cellular properties conserved from lampreys to mammals. J Physiol. doi:10.1113/jphysiol.2011.209643.
Kozlov A, Huss M, Lansner A, Kotaleski JH, Grillner S. (2009) Simple cellular and network control principles governs complex patterns of motor behavior. Proc Natl Acad Sci USA. 106:20027-32.
Jones MR, Grillner S, Robertson B. (2009) Selective projection patterns from subtypes of retinal ganglion cells to tectum and pretectum: distribution and relation to behavior. J Comp Neurol. 517:257-75.
Thompson RH, Ménard A, Pombal M, Grillner S. (2008) Forebrain dopamine depletion impairs motor behavior in lamprey. Eur J Neurosci. 27:1452-60.
Saitoh K, Ménard A, Grillner S. (2007) Tectal control of locomotion, steering, and eye movements in lamprey. J Neurophysiol. 97:3093-108.
Grillner, S. (2006) Biological Pattern Generation: The Cellu.lar and Computational Logic of Networks in Motion. Neuron 52:751-766.
Grillner, S., J. Hellgren. A. Ménard, K. Saitoh, M. Wikström (2005) Mechanisms for selection of basic motor programs – roles for the striatum and pallidum. TINS 28:364-370.
Grillner, S., H. Markram, E. De Schutter, G. Silberberg, F.E.N. LeBeau (2005) Microcircuits in action - from CPGs to neocortex. TINS vol 28, no 10:525-533. Cangiano L and Grillner S (2005) Mechanisms of Rhythm Generation in a Spinal Locomotor Network Deprived of crossed connections: The lamprey hemicord. J. Neurosci. 26: 923-935
Grillner, S. and P. Wallén (2004) Innate versus learned movements – a false dichotomy? Progress in Brain Research, 143: 3-12.
Cangiano, L. and Grillner S. (2005) Mechanisms of rhythm generation in a spinal locomotor network deprived of crossed connections: The lamprey hemicord. J Neuroscience 25, Jan 26.
Schmitt, D., R. Hill, and S. Grillner (2004) The spinal GABAergic system is a strong modulator of burst frequency in the lamprey locomotor network. J Neurophysiol 92:2357-2367.
Bem, T., J-M Cabelguen, Ö. Ekeberg, and S. Grillner (2003) From swimming to walking: a single basic network for two different behaviors. Biol. Cybern. 88:79-90.
Beloozerova, I.N., P.V. Zelenin, L.B- Popova, G.N. Orlovsky, S. Grillner, and T. Deliagina (2003) Postural control in the rabbit maintaining balance on the tilting platform. J Neurophysiol 90:3783-3793.
Zelenin, P.V, E.L. Pavlova, S. Grillner, G.N. Orlovsky, and T.G. Deliagina (2003) Comparison of the motor effects of individual vestibulo- and reticulospinal neurons on dorsal and ventral myotomes in lamprey. J. Neurophysiol. 90:3161-3167.
Hill, R.H., E. Svensson, Y. Dewael, S. Grillner (2003) 5-HT inhibits N-type but not L-type Ca2+ channels via 5-HT1A receptors in lamprey spinal neurons. Eur. J. Neurosci. 18: 2919-2924.
Grillner, S. (2003) The motor infrastructure: From ion channels to neuronal networks. Nature Reviews Neuroscience, 4: 573-586.
Cangiano, L. and S. Grillner (2003) Fast and slow locomotor burst generation in the hemispinal cord of the lamprey. J. Neurophysiol. 89:2931-2942.
Svensson, E., M.A Wikström, R.H. Hill, and S. Grillner (2003) Endogenous and exogenous dopamine presynaptically inhibits glutamatergic reticulospinal transmission via an action of D2-receptors on N-type Ca2+ channels. Europ. J. Neuroscience 17: 447-454.
Grillner, S. and P. Wallén (2002) Cellular bases of a vertebrate locomotor system –steering, intersegmental and segmental co-ordination and sensory control. Brain Research Reviews 40: 92-106.
Svensson, E, Grillner S., and Parker D. (2002) Synaptically evoked membrane potential oscillations induced by substance P in lamprey motor neurons. J Neurophysiol. Jan;87(1):113-21.
Grillner, S. (2002) Fundamentals of motor systems. In L.R. Squire, F.E. Bloom, S.K. Mc Connell, J.L. Roberts, N.C. Spitzer, M.J. Zigmond (Eds.) Fundamental Neuroscience, 2nd edition, Academic Press: 753-766.
Cangiano, L., P. Wallén and S. Grillner (2002) Role of apamin-sensitive KCa channels for reticulospinal synaptic transmission to motoneuron and for the afterhyperpolarization. J. Neurophysiology 88: 289-299.
Grillner, S. (2002) The spinal locomotor CPG: a target after spinal cord injury. In: L. McKerracher, G. Douchet and S. Rossignol (Eds) Progress in Brain Research 137:97-108.
Kozlov, A., J. Hellgren Kotaleski, E. Aurell, S. Grillner and A. Lansner (2001) Modeling of substance P and 5-HT induced synaptic plasticity in the lamprey spinal CPG: Consequences for network pattern generation. J. Comput. Neurosci. 11:183-200.
Hu, GY., Z. Biro, R. Hill and S. Grillner (2002) Intracellular QX-314 causes depression of membrane potential oscillations in lamprey spinal neurons during fictive locomotion. J. Neurophysiol. 87:2676-2683.
Selected articles
Cangiano L and Grillner S (2005) Mechanisms of Rhythm Generation in a Spinal Locomotor Network Deprived of crossed connections: The lamprey hemicord. J. Neurosci., 26, 923-935
Grillner, S. (2003) The motor infrastructure: From ion channels to neuronal networks. Nature Reviews Neuroscience, 4: 573-586.
Parker, D., W. Zhang & S. Grillner (1998) Substance P modulates NMDA responses and causes long-term protein synthesis-dependent modulation of the lamprey locomotor network. J. Neurosci. 18(12):4800-4813.
Grillner, S. (1996) Neural networks for vertebrate locomotion. Scientific American. January. 64-69.
Bacskai, B.J., P. Wallén, V. Lev-Ram, S. Grillner & R.Y. Tsien (1995) Activity-related calcium dynamics in lamprey motoneurons as revealed by video-rate confocal microscopy. Neuron 14. 19-28.
Schotland, J., O. Shupliakov, M. Wikström, L. Brodin, M. Srinivasan, Z. You, M. Herrera-Marschitz, W. Zhang, T. Hökfelt & S. Grillner. (1995) Control of lamprey locomotor neurons by colocalized monoamine transmitters. Nature. 374. 266-268.
Ekeberg, Ö., A. Lansner & S. Grillner (1995) The neural control of fish swimming studied through numerical simulations. Adaptive Behavior 3. 363-384 (MIT Press).
Grillner, S. & T. Matsushima (1991) The neural network underlying locomotion in lamprey-synaptic and cellular mechanisms. Neuron 7. 1-15.
Alford, S. & S. Grillner (1991) The involvment of GABAB receptors and coupled G-proteins in spinal GABAergic presynaptic inhition. J. Neurosci. 11. 3718-3726.
A.P. Georgopoulos & Grillner, S (1989) Visuomotor coordination in reaching and locomotion. Science 245. 1209-1210.
Wallén, P. & S. Grillner (1987) N-Methyl-D-Aspartate receptor-induced, inherent oscillatory activity in neurons active during locomotion in the lamprey. J. Neurosci. 7. 2745-2755.
Buchanan, J.T. & S. Grillner (1987) Newly identified 'glutamate interneurons' and their role in locomotion in the lamprey spinal cord. Science 236. 312-314.
Grillner, S. (1985) Neurobiological bases of rhythmic motor acts in vertebrates. Science 228.143-149.
Grillner, S., T. Williams & P-C Lagerbäck (1984) The edgecell, a possible intraspinal mechanoreceptor. Science 223. 500-503
Grillner, S. (1975) Locomotion in vertebrates - Central mechanisms and reflex interaction. Physiol. Rev. 55. 247-304.
Grillner, S. & T. Hongo (1972) Vestibulospinal effects on motoneurones and interneurones in the lumbosacral cord. In: "Basic aspects of central vestibular mechanisms. Progr. In Brain Res. Vol. 37". l. pp 243-262. Brodal A. and Pompeiano O (Eds.).
Last modified: 2015-03-09