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Research Groups

Sven Ove Ögren, Ph.D.

Sven Ove Ögren

Behavioral Neuroscience Laboratory

Research Focus

The group studies integrative functions of the brain with focus on cognitive mechanisms underlying complex behaviour. This field of research, called cognitive or behavioural neuroscience, is in its character multidisciplinary in which behavioural studies are complemented by information from studies of neuroanatomy, neurochemistry and molecular biological techniques.

The work of the group centers around the role of the hippocampus in cognitive functions with a particular focus on the role of the neurochemical systems in the hippocampus and related brain areas.

The studies of cognitive functions have led to findings which have implications for both depression and schizophrenia. Cognitive dysfunctions are found in many different disorders and can be regarded as an endophenotype. However, the mechanisms underlying the various effects on cognition differ and an important current aim of the group is to characterize the pathways and neurochemical deficits behind the cognitive dysfunctions seen in depression and schizophrenia.

Current focus of the group: 1) Studies of interactions between 5-HT1A- and NMDA-receptors in the hippocampus and its implication for cognition. 2) Modulatory action of galanin on 5-HT1Areceptors in the hippocampus and in the dorsal raphe, implications for depression. 3) Interaction between the 5-HT1Breceptors and glutamatergic and cholinergic systems in the hippocampus. 4) Characterization of galanin-receptor subtypes in animal depression models. 5) Investigation of the NMDA-receptors systems involved in the cognitive deficits induced by phencyclidine. 6) An animal model for cognitive deficits in schizophrenia?

Selected Publications

Ogren SO, Eriksson TM, Elvander-Tottie E, D'Addario C, Ekström JC, Svenningsson P, Meister B, Kehr J, Stiedl O

The role of 5-HT(1A) receptors in learning and memory.

Behavioral Brain Resesarch, 2008 [Epub ahead of print]

Eriksson TM, Madjid N, Elvander-Tottie E, Stiedl O, Svenningsson P, Ogren SO

Blockade of 5-HT(1B) receptors facilitates contextual aversive learning in mice by disinhibition of cholinergic and glutamatergic neurotransmission.

Neuropharmacology, 2008 [Epub ahead of print]

Beraki S, Kuzmin A, Tai F, Ogren SO

Repeated low dose of phencyclidine administration impairs spatial learning in mice: Blockade by clozapine but not by haloperidol.

European Neuropsychopharmacology, 2008 [Epub ahead of print]

Kuteeva E, Wardi T, Lundström L, Sollenberg U, Langel U, Hökfelt T, Ogren SO

Differential role of galanin receptors in the regulation of depression-like behavior and monoamine/stress-related genes at the cell body level.

Neuropsychopharmacology, 2008 [Epub ahead of print]

Rojas P, Joodmardi E, Hong Y, Perlmann T, Ogren SO

Adult mice with reduced Nurr1 expression: an animal model for schizophrenia.

Molecular Psychiatry, 12: 756-766, 2007

Professor Sven Ove Ögren

08-524 870 74
08-30 28 75