Peter Århem, Ph.D.

The Århem Lab

Research Focus

The behavioural and perceptual states of the brain correlate with specific oscillatory patterns of electric activity. The parameters shaping these patterns include network configuration, neuronal connection strengths and the inherent firing properties of the neurons.

We are studying the factors determining the neuronal firing pattern, focusing on potassium channels, a large group of membrane proteins that are key elements in regulating neuronal resting potential and excitability.

How these ion channels interact with each other, and with the manifold of ligand-activated receptors, and how they are modified by pharmacological agents in sculpturing the firing pattern, is a major problem within the increasingly important field of systems biology.

We use mathematical and physical theory together with electrophysiological and molecular biology methods, including the voltage and patch clamp techniques, and the Xenopus ocyte preparation, to obtain information on these issues.

Thus, we are studying the principles determining the structure of the firing, the mechanisms of action for anaesthetics, antiepileptics, antiarrythmics, as well as antiparkinsonian drugs, at a molecular and atomic level, and the complex interaction between G-protein coupled receptors and effector channels. We also interact with philosophers to clarify upcoming issues in the intricate field of cognitive processing.

Selected Publications