Falk laboratory

Reprogramming and disease modeling lab

Department of Neuroscience, Karolinska Institutet

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Reprogramming to model diseases

NES cells

Reprogramming somatic cells to induced pluripotent stem (iPS) cells opens up for studies on cells from patients. To date much of our understanding of human diseases relies on our ability to study suitable pathological tissues. For diseases of the brain this is particularly difficult as there is little live brain biopsy tissue available for analysis and postmortem specimens are of limited experimental value. Reprogramming and directed differentiation of human iPS cells offers a way to meet this lack of suitable tissues by generating the necessary pathological cells for analysis. The Falk laboratory is building cellular models of human brain disorders to study the mechanism behind the disease using reprogramming, iPS cells, neural stem cell and neurons.


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