Research

Synaptic transmission

Single neuron

Network levels

Academic Background

1966 Bachelor of Arts, Biology, Westminster College,  Fulton, Missouri, U.S.A.

1975 Master of Arts, Biology, Southwest Missouri State University,  Springfield, Missouri, U.S.A.

1976 Supply Instructor Electron Microscopy, Comparative Physiology and Medical Physiology at Life Sciences Department, Southwest Missouri State University, Springfield, Missouri, U.S.A.

1981 Doctor of Philosophy, Biology, Boston University Marine Program, Woods Hole, Massachusetts, U.S.A.

1981-1982 Postdoctoral Fellowship, Muscular Dystrophy Association, University of Toronto, Scarborough, Canada.

1983-1984 Postdoctoral Fellowship, Swedish Medical Research Council/National Institutes of Health (US), Karolinska Institutet, Stockholm

1984-1985 University lecturer at GIH, Stockholm

1985-1996 First Research Engineer/Researcher, Department of Neuroscience, Karolinska Institutet, Stockholm

1997-2005 Staff Researcher, Department of Neuroscience, Karolinska Institutet, Stockholm

2005- present Associate professor, Department of Neuroscience, Karolinska Institutet.

Selected publications

Hill, R.H., P. Århem, and S. Grillner, Ionic mechanisms of 3 types of functionally different neurons in the lamprey spinal cord. Brain Res 1985. 358(1-2): p. 40-52.

Wallén, P., J.T. Buchanan, S. Grillner, R.H. Hill, J. Christenson, and T. Hökfelt, Effects of 5-hydroxytryptamine on the afterhyperpolarization, spike frequency regulation, and oscillatory membrane properties in lamprey spinal cord neurons. J Neurophysiol, 1989. 61(4): p. 759-68.

Matsushima, T., J. Tegnér, R.H. Hill, and S. Grillner, GABAB receptor activation causes a depression of low- and high-voltage- activated Ca2+ currents, postinhibitory rebound, and postspike afterhyperpolarization in lamprey neurons. J Neurophysiol, 1993. 70(6): p. 2606-19.

Brodin, L., O. Shupliakov, V.A. Pieribone, J. Hellgren, and R.H. Hill, The reticulospinal glutamate synapse in lamprey: plasticity and presynaptic variability. J Neurophysiol, 1994. 72(2): p. 592-604.

Wikström, M., R. Hill, J. Hellgren, and S. Grillner, The action of 5-HT on calcium-dependent potassium channels and on the spinal locomotor network in lamprey is mediated by 5-HT1A-like receptors. Brain Res, 1995. 678(1-2): p. 191-9.

Hu, G.Y., Z. Biro, R.H. Hill, and S. Grillner , Intracellular QX-314 causes depression of membrane potential oscillations in lamprey spinal neurons during fictive locomotion. J Neurophysiol, 2002. 87(6): p. 2676-83.

Hill, R.H., E. Svensson, Y. Dewaer and S. Grillner. 5-HT inhibits N-type but not L-type Ca(2+) channels via 5-HT1A receptors in lamprey spinal neurons. Eur J Neurosci. 2003 Dec;18(11):2919-24.

Svensson, E., M. Wickström, R.H. Hill, and S. Grillner. Endogenous and exogenous dopamine presynaptically inhibits glutamatergic reticulospinal transmission via an action of D2-receptors on N -type Ca2+  channels. Eur J Neurosci., 2003, 17:447-454.

Schmitt DE, Hill RH, Grillner S.The spinal GABAergic system is a strong modulator of burst frequency in the lamprey locomotor network. J Neurophysiol. 2004 Oct;92(4):2357-67.

Tsvyetlynska NA, Hill RH, and Grillner S. Role of AMPA receptor desensitization and the side effects of a DMSO vehicle on reticulospinal EPSPs and locomotor activity. J Neurophysiol 94: 3951-3960, 2005.

Biro Z, Hill RH and Grillner S. J Neurophysiol. 2006 Aug;96(2):931-5.   5-HT Modulation of identified segmental premotor interneurons in the lamprey spinal cord.

Collaborations

Vikman, K.S., E. Backström, K. Kristensson, and R.H. Hill, A two-compartment in vitro model for studies of modulation of nociceptive transmission. Journal of Neuroscience Methods, 2001. 105(2): p. 175-84

Vikman, K.S., K. Kristensson, and R.H. Hill, Sensitization of dorsal horn neurons in a two-compartment cell culture model: wind-up and long-term potentiation-like responses. J Neurosci., 2001. 21(19): p. RC169:1-6.

Lundkvist, G.B., K. Kristensson, and R.H. Hill, The suprachiasmatic nucleus exhibits diurnal variations in spontaneous excitatory postsynaptic activity. J. Biol. Rhythms, 2002.

Kerekes, N. F. Mennicken, D. O’Donnell, T. Hökfelt  and R. H. Hill. Galanin increases membrane excitability and enhances Ca2+ currents in adult, acutely dissociated dorsal root ganglion neurones. Eur J Neurosci., 2003 Dec;18(11):2957-66..

Brask, J., K. Kristensson and R. H. Hill. Exposure to interferon-gamma during synaptogenesis increases inhibitory activity after a latent period in cultured rat hippocampal neurons. Eur J Neurosci. 2004 Jun;19(12):3193-201.

Brask J, Chauhan A, Hill RH, Ljunggren HG, and Kristensson K. Effects on synaptic activity in cultured hippocampal neurons by influenza A viral proteins. J Neurovirol 11: 395-402, 2005.

Nygard M, Hill RH, Wikstrom MA, and Kristensson K. Age-related changes in electrophysiological properties of the mouse suprachiasmatic nucleus in vitro. Brain Res Bull 65: 149-154, 2005.

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Last modified: 2009-06-02